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This is the largest family of catfishes in Asia with around 100 species known.

There is an adipose fin present (confluent with caudal in some genera and consisting of a small spine in the elongate Sisor); dorsal fin base short, fin with or without a spine, adhesive apparatus in thoracic region present or absent; four pairs of barbels (however, the monotypic Sisor has one maxillary pair and five pairs on the lower jaw). They are not too well known to aquarists as they are only sporadically exported. The most common being the genus, Gagata, Bagarius and Glyptothorax. Known collectively as "hill stream catfishes" due to many of them being found in fast flowing rivers. The Sisorids vary in body shape and are probably the hardest family for the aquarist to identify.

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